Francis Y Lee, MD, PhD, FAAOS

Professor of Orthopaedics and Rehabilitation; Professor with Tenure, Unmodified Ladder Track, Musculoskeletal Tumors, Pediatric Orthopedics, and Infection Service; Vice Chair of Academic, Scientific, and Research Affairs, Department of Orthopedics & Rehabilitation

Departments & Organizations

Orthopaedics & Rehabilitation: Musculoskeletal Oncology | Ortho Clinical Faculty

Center for Musculoskeletal Care

Faculty Research

Yale Medicine

Biography

  • Affiliation: Professor with Tenure, Orthopedic Surgeon and Scientist, Department of Orthopedic Surgery, School of Medicine, Yale University (2016-Present); Professor with Tenure and Robert Carroll & Jane Chace Carroll Professor, Columbia University, New York (2012-2016); Orthopaedic Attending & Chief of Orthopaedic Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York (1999-2016)
  • Clinical Practice Locations: Greenwich Hospital, Stamford Office, and Yale New Haven Hospital System
  • Clinical Expertise: Musculoskeletal Bone and Soft Tissue Tumors & Complex Limb Reconstruction in Adults and Children; Metastatic Cancers to Bone (Breast, Prostate, Thyroid and Others); Osteomyelitis; Pediatric Orthopedics; Osteoid Osteoma, Enchodroma, Osteochondroma, Metabolic and Genetic Bone Diseases, Spine Tumors
  • Research Interest: NIH R01-funded research programs in metastatic cancer-induced bone loss, fracture healing, regenerative orthopedics, and bone infection. Our lab is located in Tompkin 5 Orthopedic Research Laboratories.
  • Administration: Vice Chair of Academic, Scientific, and Research Affairs
  • Education: American Board of Orthopaedic Surgery Written Question Task Force, Orthopaedic Research Society Mentorship Committee, New York Orthopaedic Pathology Review Course
  • Current Research Programs:

- NIH/NIAMS R01 (2015-2021; PI: Francis Y. Lee, M.D.): Infection and bone destruction; Eradication of bone destruction

- NIH/NCI R01 (2015-2021; PI: Francis Y. Lee, M.D.): Interactions between metastatic cancers and bone; Bone loss

- NIH/NIAMS R01 (2009-2019; PI: Francis Y. Lee, M.D.): Inflammation and bone loss; Osteoclastogenesis

- NIH/NIBIB R01 (2007-2017; PI: Francis Y. Lee, M.D.): Biomaterials interface biology

- Musculoskeletal Transplantation Foundation (2013-2017): Enhanced Allograft Incorporation with Growth Factors

- Department of Defense (2010-2015; PI: Francis Y. Lee, M.D.): 3D printed scaffolds for bone and cartilage defects

  • Interactions with Undergraduate Students, Medical Students, M.D.-Thesis Medical Students, M.D.-Ph.D. Candidate, Graduate Students, and Post-doctoral Fellows: Please send inquiries to francis.lee@yale.edu for research and clinical opportunities.
  • Mentoring and Supporting Junior Faculty, Fellows, and Residents: Assisting Career Development Awards or Grants. Academic Promotion Guidance; Primary Mentorship for NIAMS K08 Career Development Award for an Orthopaedic Surgeon at Yale Orthopaedics & Rehabilitation (2017-2022); Mentorship for OREF Residents & Faculty Award
  • Yale University: Yale University Saybrook College Fellow

Education & Training

PhD Seoul National University College of Medicine, Orthopedic Basic Science (1992)
MD Seoul National University College of Medicine, Doctor of Medicine (1986)
Clinical Orthopedic Fellowship Hospital for Sick Children
Clinical Orthopedic Fellowship Harvard Medical School (Mass General Hospital & Boston Children's Hospital)
Orthopedic Research Fellowship Mount Sinai School of Medicine
Orthopaedic Residency New Jersey Medical School
Orthopaedic Residency Seoul National University Hospital
Undergraduate Student University of Maryland at U.S. 8th Army, Seoul, Korea
Premed & Doctor of Medicine Seoul National University College of Medicine
Board Certification AB of Orthopaedic Surgery, Orthopaedic Surgery (2001)

Honors & Recognition

  • Best Poster Award, 2nd Place; Osteolytic Metastatic CancersMusculoskeletal Tumor Society (2016)

  • Kappa Delta Ann Doner Vaughn AwardAmerican Academy of Orthopedic Surgeons (2016)

  • Best Paper Award, Second PlaceEuropean Musculoskeletal Tumor Society (2014)

  • J. Neff AwadMusculoskeletal Transplantation Foundation (2014)

  • Career Development AwardOrthopedic Research and Education Foundation (2006)

  • AAOS/OREF/ORS Clinician Scientist Traveling Fellowship AwardAAOS (2005)

  • AOA Resident Traveling Fellowship AwardAmerican Orthopedic Association (1996)

  • Young Investigator AwardInternal Society for Fracture Repair (1996)

Professional Service

  • National Institute of Health Skeletal Biology, Structure, and Reconstruction (SBSR) Study Section (2015) NIH SBSR Study Section Permanent Member

  • Musculoskeletal Tumor Society (2015) Research Committee

  • Department of Defense Orthopaedic Trauma PRMRP Study Section Chair (2014 - 2014)

  • American Academy of Orthopedic Surgeons (2013) Tumor Program Committee

  • American Academy of Orthopedic Surgeons, Orthopaedic Research Society, Orthopedic Research and Education Foundation (2012 - 2014) Clinician Scholar Development Program Chair

  • American Academy of Orthopedic Surgeons, Orthopaedic Research Society, Orthopedic Research and Education Foundation (2011 - 2015) New Investigator Mentoring Workshop Chair

  • American Board of Orthopedic Surgery (2008) Orthopedic Surgery Board Written Question Writing

  • NIH, NCI, 2013 NIAMS P50 and P30 Study Section Panel; NIH CSR MTE, SBDD, Skeletal Biology Structure Regeneration (Standing Member 2015-2019), SEP Panel Members; 2017 NIAMS Musculoskeletal Center P50 CORT Review Panel; 2017 NIAMS Musculoskeletal Clinical Research Center P30 Review Panel (2007 - 2016)

  • American Academy of Orthopedic Surgeons (2006 - 2012) Research Development Committee

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Contact Info

Francis Y Lee, MD, PhD, FAAOS
Patient Care Locations
Yale Physicians Building
800 Howard Avenue

New Haven, CT 06519
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Bendheim Cancer Center At Greenwich Hospital
77 Lafayette Place

Greenwich, CT 06830
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Orthopaedics - Milford
48 Wellington Road

Milford, CT 06461
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Yale Orthopaedics & Rehabilitation at Stamfort, CT260 Long Ridge Road
Stamford, CT 06902
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Mailing Address
47 College Street Second Floor
New Haven, CT 06520

Curriculum Vitae

Cancer-Induced Bone Loss